TL;DR: An excellent examination of a Progenitor hard at work, and the web of plots (tying to Mage, Werewolf, and Vampire) that swirl around him. The smattering of toys and rotes at the end are the icing on a delicious cake.
Progenitors Crash Cart: Issue 2 focuses on Dr. Evan Grillard, a model member of the Progenitors; by day working to help the medically underserviced and impoverished of Tampa, while at night... he engages in more questionable practices. Because Dr. Evan Grillard is a barabii, a Mage turned Nephrandus.
The majority of the book focuses on Dr. Evan's methods, both for work and for keeping himself safe from discovery (as well as the unfortunate fate of those who pierce his deception), and how a subset of Tampa's other supernaturals think about him. Grillard is an excellent character in himself, and better for having such a deep well of potential story hooks in so many directions. The ties to Tampa are also fairly shallow, which would make Grillard easy to transplant to other settings and games as needed.
The tail of the book has a handful of Artifacts and Rotes (excuse me; Enhancements and Procedures) which could see broad use in any Mage game, either as toys for the players or tools for antagonists.
The layout is generally solid (apart from the author's propensity to italicize words for emphasis maybe a little too often). The interior art is also excellent; in particular, the twisted Major Arcana style full page illustrations are just the right kind of grotesque and disturbing.
I can only find two criticism worth raising; first, we learn almost nothing about the other members of Grillard's Amalgam. Considering the detail we get about more tangential relationships, this feels like a sad oversight. Second, Dr. Grillard himself suffers from the same sort of stat inflation (Enlightenment 8? Seven spheres, rated at 3, and Life at 4?) very common to Mage NPCs.
But neither of these are remotely deal breakers. Crash Cart 2 delivers well on what it promises.